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Interleukin 33 (IL-33) is a cytokine that functions as an alarmin and is released from damaged tissue. The receptor for IL-33 is ST2, which exists as membrane bound and soluble forms. Levels of IL-33 and soluble ST2 (sST2) are elevated in some inflammatory diseases. Amyotrophic lateral sclerosis (ALS) is a disease that is due to loss of motor neurones, with some neuro-inflammation at the site of pathology...
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