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Esophageal adenocarcinoma is increasing in incidence and arises in a background of reflux induced inflammation, metaplasia, and dysplasia. The proinflammatory transcription factor nuclear factor-kappa B (NF-κB) has a central role in inflammation and tumorigenesis. Because a role for NF-κB has been implicated in the pathogenesis of esophageal cancer, this transcription factor has been the focus of...
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