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— Oxidative stress is one of the key factors responsible for brain tissue damage in ischemia; this points to the use of antioxidants under these conditions. One of the promising antioxidants for the therapy of ischemic stroke is a natural dipeptide carnosine. In this study the neuroprotective effect of dietary carnosine administration has been investigated in an experimental model of focal cerebral...
Cerebral oxidative stress (OS) contributes to the pathogenesis of hepatic encephalopathy (HE). Existing evidence suggests that systemic administration of l-histidine (His) attenuates OS in brain of HE animal models, but the underlying mechanism is complex and not sufficiently understood. Here we tested the hypothesis that dipeptide carnosine (β-alanyl-l-histidine, Car) may be neuroprotective in thioacetamide...
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