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Angioplasty followed by stent placement, bare or drug-eluting, proved to be a major step forward in the treatment of coronary and carotid artery disease. It was soon recognized that patients undergoing these procedures presented with restenosis within 6 months. The cause of these failures was the development of intimal hyperplasia. Aspirin, acetylsalicylic acid, soon became a focus of therapeutic...
Aims/hypothesis Recent studies have identified the involvement of inhibitor IκB kinase (IKK) in the pathogenesis of insulin resistance. To investigate the mechanism involved, we examined the role of nuclear factor κB (NF-κB), the distal target of IKK, in hepatic glucose metabolism. Methods To inhibit NF-κB activity, db/db mice were infected with adenovirus expressing the IκBα super-repressor. ...
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