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The effects on neuronal nitric oxide synthase (NOS) of protein kinase C (PKC) activation in rat cerebellar slices and of in vitro phosphorylation by PKC were compared. Incubation of slices with 1-aminocyclopentane-1,3-trans-dicarboxylic acid (trans-ACPD) or phorbol myristate acetate (PMA) in the presence of okadaic acid (OA) shifted the calcium sensitivity of neuronal NOS in the homogenate or in...
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