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Abstract: Melatonin has been shown to modulate glucose metabolism by influencing insulin secretion. Recent investigations have also indicated a regulatory function of melatonin on the pancreatic α‐cells. The present in vitro and in vivo studies evaluated whether melatonin mediates its effects via melatonin receptors and which signaling cascade is involved. Incubation experiments using the glucagon‐producing...
Abstract: Recent investigations have demonstrated that melatonin influences carbohydrate metabolism mediated by insulin‐inhibiting effects on pancreatic β‐cells. This study evaluated whether melatonin has also an effect on pancreatic α‐cells and glucagon expression as well as the glucagon secretion in vitro and in vivo. Glucagon‐producing pancreatic α‐cell line αTC1 clone 9 (αTC1.9) was used, which...
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