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β-amyloid (Aβ) has been suggested as a potent neurotoxic agent. The Aβ-targeted immunotherapy aims to clear diffuse amyloid deposits and reverse memory deficits in Alzheimer's disease. We generated a human single chain variable domain antibody fragment (scFv) against Aβ 40 , termed E3, by screening a phage antibody library. E3 scFv could recognize Aβ in human cerebral cortex. It was able not...
Amyloid β peptide (Aβ), which is deposited as insoluble fibrils in senile plaques, is thought to play a role in the neuropathology of Alzheimer's disease. We have developed a model in which rat embryonic cerebral cortical or hippocampal neurons are seeded onto culture dishes containing deposits of substrate-bound, fibrillar Aβ. The neurons attached rapidly to Aβ 1-40 and Aβ...
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