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Pathophysiological remodeling of cardiac function occurs at multiple levels, spanning the spectrum from molecular and subcellular changes to those occurring at the organ-system level. Of key importance to arrhythmias are changes in electrophysiological and calcium handling properties at the tissue level. This review discusses how high-resolution optical mapping of action potential and calcium transients...
Heart failure increases autonomic nerve activities and changes intracellular calcium (Ca i ) dynamics.The purpose of this study was to investigate the hypothesis that abnormal Ca i dynamics are responsible for triggered activity in the pulmonary veins (PVs) during acetylcholine infusion in a canine model of heart failure.Simultaneous optical mapping of Ca i and membrane potential...
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