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Excitotoxic neuronal death has been clearly documented in the adult brain following status epilepticus (SE), a state of uninterrupted seizure activity that may last for hours. The severity and duration of SE determine the extent of neuronal injury; in most animal models damage is observed with durations of one hour or longer. Severity, duration and rate of onset may also influence the extent to which...
Cannabinoids are known to control the cell survival/death decision, leading to different outcomes that depend on the nature of the target cell and its proliferative or differentiation status. Cannabinoids induce growth arrest or apoptosis in a number of transformed cells in culture. They do so by modulating key cell signalling pathways involved in the control of tumour cell fate. The best-characterised...
Summary For a drug to be effectivein vivoin-vitroprotection must be translated to studies of both global (transient forebrain ischemia) to discern “cellular” neuroprotection (cytoprotection) and focal ischemia to evaluate “parenchymal” neuroprotection (infarct reduction). Drug concentrations that suggest that the mechanism is activein vitromust translate to drug levels that achieve cytoprotection...
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