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p53 acts as a central mediator of the cellular response to stressful stimuli. The growth-suppressive function of p53 is lost with mutation and this occurs commonly in human cancer. In addition to suppressing cancer development and progression, wild-type p53 further confers chemo-sensitivity and radio-sensitivity upon tumor cells. Accumulated evidence over the last two decades that wild-type p53 activity...
Abstract. P73, a new p53 homologue, has been recently identified as a candidate tumor suppressor gene. Purpose: We studied the alterations in p73 in a panel of human cancer cell lines treated with the chemotherapeutic agent, Adriamycin (ADR), in comparison with the changes in p53. Methods: P73 and p53 mRNA and protein were determined using semiquantitative reverse transcription-polymerase chain reaction...
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