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A hierarchy of minimal mathematical models of the dynamics of the p53-Mdm2- microRNA system has been developed. The models are based on differential equations with a time delay, describing complex interaction mechanisms in the signal system of the p53 protein. We consider two types of interaction of p53 with microRNAs: a positive direct connection and a positive feedback. The feedback of microRNA-p53...
Modulation of intracellular protein–protein interactions has been – and remains – a challenging goal for the discovery and development of small-molecule therapeutic agents. Progress in the pharmacological targeting and understanding at the molecular level of one such interaction that is relevant to cancer drug research, viz. that between the tumour suppressor protein p53 and its negative regulator...
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