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Nearly two thirds of American adults are overweight or obese, placing them at increased risk of obesity-related chronic diseases, including cancer. Although it has been known for quite some time that obesity increases initial risk of breast, colon, and endometrial cancer, new data implicate obesity as a risk factor for ovarian and thyroid cancers. In addition, recent evidence shows that obesity is...
12-lipoxygenase (12-LOX) pathway which produces 12-HETE and hepoxiline HXA3 and HXB3, and induces production of reactive oxygen species and inflammation is increasingly being implicated in variety of cancers, including those of colorectal and thyroid cancers. Hence, we examined whether the functional polymorphism of 12-LOX (mRNA A835G; Protein Gln261Arg) has any association with human colorectal and...
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