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Purpose Relapsed high-risk neuroblastoma patients still have a poor prognosis. This phase-II trial assessed a new topotecan containing chemotherapy approach in patients with active disease. Methods Chemotherapy consisted of topotecan (1.0 mg/m2/day 168-h continuous infusion), cyclophosphamide (100 mg/m2/day 1-h-infusion days 1–7 starting 6 h prior to topotecan), and etoposide (100 mg/m2/day 1-h-infusion...
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