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The cannabinoid receptor family currently includes twotypes:CB1, characterized in neuronal cells and brain, and CB2, characterized in immune cells and tissues. CB1 and CB2 receptors are members of the superfamily of seven-transmembrane-spanning (7-TM) receptors, having a protein structure defined by an array of seven membrane-spanning helices with intervening intracellular loops and a C-terminal domain...
As mediators of relaxation of vascular smooth muscle, cGMP and cAMP signaling pathways have become an important focus of drug development for pulmonary hypertension. Phosphodiesterases (PDEs), the enzymes that catalyze hydrolytic cleavage of the 3’-phosphodiester bond of the cyclic nucleotides, controlling intracellular levels, are obvious drug targets. PDEs have a wide distribution in normal tissues...
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