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Background. This review describes the development of a research line on the role of serotonin (5-HT) in experimental anxiety that was initiated in 1969, in the laboratory founded by P.B. Dews, W.H. Morse and R.T. Kelleher at the Harvard Medical School, and has evolved until this date. Results. Initially, it was found that two non-selective 5-HT receptor antagonists released punished responding in...
Rationale. A host of factors that modulate the increases produced by benzodiazepines on responding suppressed by punishment have been described. Nonetheless, the necessary and sufficient conditions for the anxiolytic-like activity in this animal model have not been fully delineated. Objectives. The present experiments sought to determine the necessity of the reinforcing event (food delivery), the...
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