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Chalcones are hydrophobic polyphenols with extremely poor aqueous solubility. In this study, we prepared a new chalcone derivative-loaded nanoparticle (DPP-23-loaded NP) using a monomethoxy poly(ethylene glycol)-poly(D,L-lactide) copolymer which, in an aqueous environment, spontaneously forms a micellar formation with an average particle size of 20.8 nm. Exposure to various concentrations of DPP-23-loaded...
The emerging nanotechnology-based drug delivery holds tremendous potential to deliver chemotherapeutic drugs for treatment of multidrug resistance (MDR) cancer. This drug delivery system could improve the pharmacokinetic behavior of antitumor drugs, deliver chemotherapeutic drugs to target sites, control release of drugs, and reduce the systemic toxicity of drugs in MDR cancer. This review addresses...
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