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Nutrients modulate host metabolism that lead to changes in biological and molecular responses. Thus, it is not surprising that tumor cells also are affected by changes in host nutrition. Because tumors have altered or mutated genes, they often respond differently to metabolic changes than the host. Many tumors have altered or specific requirements for amino acids, and restriction often can curtail...
While it is very clear that activation of β-catenin through the canonical Wnt pathway plays a role in a multitude of human cancers, it has also been noted time and time again that activation of β-catenin is observed in tumors without any clear mutation in any of the major components of the pathway or any increase in Wnt signaling. This suggests that other factors maybe capable of inducing activation...
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