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Vascular endothelial growth factor (VEGF) signaling is linked to invasiveness and aggressive disease in colorectal cancer (CRC), and two VEGF-directed agents, bevacizumab and aflibercept, are currently approved for treatment of metastatic disease. CRC cells are a major source of VEGF that is secreted into the tumor environment where it can associate with VEGF receptors on neighboring endothelial cells...
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