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We have analyzed the effects of agonists acting at different classes of metabotropic glutamate receptors (mGluRs) on paired pulse depression (PPD) at the medial perforant path/granule cell synapse. Drugs were bath applied and paired pulses delivered at 3-min intervals during control and during drug application. Both 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S3R-ACPD, 100 μM), which acts...
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