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To investigate the protective effects of 17β-estradiol postconditioning against ischemia/reperfusion (I–R)-induced gastric mucosal injury in rats.The animal model of gastric ischemia/reperfusion was established by clamping of the celiac artery for 30min and reperfusion for 30min, 1h, 3h, 6h, 12h or 24h. 17β-estradiol at doses of 5, 50 or 100μg/kg (rat) was administered via peripheral veins 2min before...
Testicular macrophages can convert cholesterol into 25-hydroxycholesterol which strongly stimulates Leydig cell testosterone production. We demonstrated that 25-hydroxycholesterol reduced cholesterol biosynthesis in adult rat Leydig cells. This oxysterol can also be cytotoxic. As hydroxylated cholesterol can induce apoptosis in various cells, we investigated cell death produced by 25-hydroxycholesterol...
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