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Background. The inflammatory cascade has emerged as the primary mediator of reperfusion injury. Nuclear factor κB (NF-κB) is a rapid response transcription factor that activates genes responsible for the mediators of inflammation. Heat shock protein 70 (HSP70) has been shown to protect against lung injury. We hypothesized that the antioxidant pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-κB...
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