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Glutathione (l-γ-glutamyl-l-cysteinylglycine, GSH), is a vital intra- and extracellular protective antioxidant. Glutathione is synthesized from its constituent amino acids by the sequential action of γ-glutamylcysteine synthetase (γ-GCS) and GSH synthetase. The rate-limiting enzyme in GSH synthesis is γ-GCS. Gamma-GCS expression is modulated by oxidants, phenolic antioxidants, and inflammatory and...
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