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Cardiovascular disease is the principal cause of death in patients with type 2 diabetes (T2DM). Exposure of the vasculature to metabolic disturbances leaves a persistent imprint on vascular walls, and specifically on smooth muscle cells (SMC) that favours their dysfunction and potentially underlies macrovascular complications of T2DM. Current diabetes therapies and continued development of newer treatments...
Résumé Le syndrome métabolique (SMet) est un phénotype courant qui se manifeste chez quelque 24 % de la population des États-Unis. Il est associé à un risque accru de diabète de type 2 et de la maladie cardiovasculaire. Même s’il n’existe pas de définition universellement acceptée pour le SMet, les sujets atteints présentent un assemblement de traits, y compris l’obésité abdominale, l’hypertension...
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