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Pulsatile stretch and shear stress in hypertension are reported to participate in atherosclerosis. The relationship between mechanical stress and atherosclerosis has been investigated from the point of biochemical molecules, such as angiotensin, endothelin, cytokines and oxidative stress. In particular, reactive oxygen species are up-regulated by mechanical stretch and participate in advances of atherosclerosis...
It has been suggested that circulating concentrations of hepatocyte growth factor (HGF) are increased in individuals with vascular endothelial damage, such as in hypertensive patients and subjects with atherosclerosis. Because the influence of genetic variation of HGF has not been examined, we identified single nucleotide polymorphisms (SNPs) in the HGF gene, and investigated the association between...
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