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Background Poultry breeding programs have been focused on improvement of growth and carcass traits, however, this has resulted in correlated changes in internal organ weights and increased incidence of metabolic disorders. These disorders can affect feed efficiency or even cause death. We used a high density SNP array (600 K, Affymetrix) to estimate genomic heritability, perform genome-wide association...
Purpose. The aim of this study was to assess in vivo which organs contribute to the first-pass metabolism of diltiazem. Methods. Anaesthetized rabbits received diltiazem into the thoracic aorta (TA) (1 mg/kg), jugular vein (JV) (2 mg/kg), portal vein (PV) (4 mg/kg) or small intestine (SI) (5 mg/kg). Serial blood samples were...
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