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Affektive Störungen sind Kernsymptome der Schizophrenie. Neuronale Korrelate dieser Veränderungen können mit molekularen, strukturellen und funktionellen Methoden der Bildgebung des Gehirns untersucht werden. In dieser Übersichtsarbeit werden Bildgebungsstudien vorgestellt, mit dem Schwerpunkt auf affektive Symptome und Veränderungen in der emotionalen Verarbeitung bei schizophrenen Patienten. Studien...
Rationale Current perspectives on the pathophysiology of schizophrenia direct attention to serotonergic (serotonin, 5-HT) dysregulation in the prodrome or at-risk mental state (ARMS). Objective To study the cerebral 5-HT2A receptor (5-HT2AR) in the ARMS with [18F]altanserin positron emission tomography (PET) and a bolus-infusion paradigm. Materials and methods We quantified the spatial distribution...
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