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The liver is a multifunctional organ that has important roles such as metabolism, synthesis, and detoxification. Enhanced hepatocyte apoptosis and impaired liver regeneration are the most common liver disorders in acute liver failure. Hepatocyte apoptosis also emerges as a fundamental component of chronic liver diseases. Liver tissue fibrosis is triggered by hepatocyte apoptosis, and the excess fibrosis...
Most anticancer therapies commonly used in the treatment of human cancer, e.g., chemotherapy, γ-irradiation, immunotherapy, or suicide gene therapy, kill tumor cells by triggering cell death pathways including apoptosis in cancer cells. Hence, the failure to activate such pathways may lead to the resistance of cancers to current treatment approaches. A better understanding of the molecular events...
Histone deacetylas inhibitors (HDIs) are a novel prospective group of potential anti-cancer agents, some of them being tested in a clinical setting. The major mode of action of these compounds is inhibition of the cell cycle transition and, consequently, differential regulation of a number of genes necessary for cell proliferation, while favouring expression of genes rather associated with anti-proliferative...
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