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Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are mature B-cell lymphoid neoplasms with an identical immunophenotype that are currently thought to be very closely related if not identical. As a result, the current World Health Organization classification of hematolymphoid diseases has designated this disease as chronic lymphocytic leukemia/small lymphocytic lymphoma. Patients...
Apoptosis plays a pivotal role in the development and homeostasis of all multicellular organisms. It has been shown that dysregulation of apoptosis can lead to many human diseases, including neoplastic, cardiovascular and degenerative disorders. As a component of the apoptosome, a caspase-activating complex, Apaf-1 plays a central role in the mitochondrial caspase activation pathway of apoptosis....
Cutaneous melanoma is in general highly refractory to chemotherapy and radiotherapy. Melanoma has been resistant to therapeutics that induce apoptosis leading to a poor outcome in development of effective therapeutics. Over the years countless experimental drugs have been tested to induce apoptosis to melanoma cells in patients but very few have gone beyond phase III treatment. As melanoma progresses...
Apaf-1, as a core component of the apoptosoma, is a protein which requires to be strictly regulated. This regulation is evidenced by the growing number of protein partners that have been described, including among others, controversial interactions with members of the Bcl-2 family, heat shock and cell cycle proteins. Furthermore, studies directed to the identification of Apaf-1 chemical modulators...
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