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Background Argonaute-2 (Ago2) is an essential component of microRNA biogenesis implicated in tumourigenesis. However Ago2 expression and localisation in breast cancer remains undetermined. The aim was to define Ago2 expression (mRNA and protein) and localisation in breast cancer, and investigate associations with clinicopathological details. Methods Ago2 protein was stained in breast cancer cell...
Background The global pandemic of obesity and the metabolic syndrome are leading causes of mortality and morbidity. Bariatric surgery leads to sustained weight loss and improves obesity-associated morbidity including remission of type 2 diabetes. MicroRNAs are small, endogenous RNAs that regulate gene expression post-transcriptionally, controlling most of the human transcriptome and contributing to...
Background The potential of circulating miRNAs as biomarkers of tissue function, both in health and disease, has been extensively demonstrated in humans. In addition, circulating miRNA biomarkers offer significant potential towards improving the productivity of livestock species, however, such potential has been hampered by the absence of information on the nature and source of circulating miRNA populations...
Infolge des humanen Genomprojekts wurde bekannt, dass lediglich 1–3 % der Gentranskripte tatsächlich Proteine kodieren und der wesentlich größere Anteil als nichtkodierende Ribonukleinsäuren (ncRNAs) vorliegt. Diese ncRNAs nehmen großen Einfluss auf verschiedenste physiologische und pathologische Mechanismen eines Organismus. Vor allem microRNAs (miRNAs) und lange nichtkodierende RNAs (lncRNAs), welche...
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