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Glatiramer acetate is a disease-modifying drug approved for the treatment of relapsing-remitting multiple sclerosis. Since its discovery almost four decades ago, and in particular since the observation of its beneficial clinical effects in the late 1980s and early 1990s, numerous data have been generated and contribute pieces of a puzzle to help explain the mechanism of action of glatiramer acetate...
The immune system is homeostatically regulated to maintain a balance between triggering of inflammatory responses and protecting against self-directed autoimmunity. In autoimmune diseases, such as multiple sclerosis, this balance is disrupted. T regulatory cells, characterised by the expression of the cell surface marker CD25 and the transcription factor FoxP3, play a key role in maintaining this...
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