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Aims/hypothesis. Prolactin secretion is often reduced in insulin dependent diabetes mellitus, but little is known about the mechanism involved. Since changes in the hormonal environment modulate cell proliferation, death and cellular makeup of the anterior pituitary, we have analysed whether the number of lactotrophs is reduced in diabetic rats. Methods. Streptozotocin induced diabetic rats were maintained...
Bcl-2 oncogene and Bax gene play an important role in regulating apoptosis. In the present study, the expression of bcl-2 and bax was investigated and correlated with apoptosis in a series of 81 pituitary adenomas. Bcl-2 and bax proteins were localized by immunohistochemistry and the histoscore (HSC) was assessed by multiplying the immunohistostaining grade (1 to 4) by the staining intensity grade...
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