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Metformin is best known as a foundational therapy for type 2 diabetes but is also used in other contexts in clinical medicine with a number of emerging and potential indications. Many of its beneficial effects may be mediated by modest effects on weight loss and insulin sensitivity, but it has multiple other known mechanisms of action. Current clinical uses beyond type 2 diabetes include: polycystic...
Aim
To compare the clinical efficacy and safety of glargine‐U100 (Lantus/Gla‐100) with glargine‐U300 (Toujeo/Gla‐300) in adult patients with type 2 diabetes (T2D) and type 1 diabetes (T1D).
Materials and Methods
A literature search on Gla‐300/Gla‐100 in diabetes management was conducted using the MEDLINE/Embase/Cochrane databases from inception to 10 January 2021. Eligible studies considered for...