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Purpose. Heptaplatin is a newly developed platinum derivative which has been reported to be less toxic than cisplatin. This study was designed to evaluate the nephrotoxicity of heptaplatin in comparison with that of cisplatin. Methods. Previously untreated advanced gastric cancer patients with normal renal function were randomly assigned into either group I (heptaplatin 400mg/m2 i.v. over 1h on day1...
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