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Accumulating evidence indicates that inflammation plays a critical role in cancer development. Cyclooxygenase-2 (COX-2) is a rate-limiting enzyme for prostanoid biosynthesis, including prostaglandin E2 (PGE2), and plays a key role in both inflammation and cancer. It has been demonstrated that inhibition of COX-2 and PGE2 receptor signaling results in the suppression of tumor development in a variety...
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