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11β-Hydroxysteroid dehydrogenase type 1 (11β−HSD1) catalyzes intracellular regeneration of corticosterone and cortisol, thereby enhancing glucocorticoid action. Inhibition of 11β−HSD1 reverses the deficits in cognition with aging, a state of elevated glucocorticoid levels. However, any impact of 11β−HSD1 inhibition during high glucocorticoid states in younger animals is unknown. Here we examined whether...
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