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Both clinical findings and results of experiments with animal models of alcoholic hepatitis have shown the importance of cytokine-mediated cell-cell interactions in the onset of ethanol-induced liver damage. Proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1beta (IL-1β), and interleukin-6, are released from Kupffer cells or infiltrating neutrophils and macrophages...
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