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Opiate intake was studied in rats, which were given free choice between water and etonitazene (ETZ) solutions (2, 4, and 8 mg/l) for 30 weeks. After an abstinence of 19 weeks, the opiate was reoffered. The long-term course of intake could be subdivided in three phases: a period of controlled intake (25 weeks), a period of increasing consumption (week 25-30), and the stage of drug addiction (retest)...
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