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The American Society of Clinical Oncology recently published a Clinical Practice Guideline entitled “Appropriate Chemotherapy Dosing for Obesity Adult Patients with Cancer.” The panel recommended that full weight (actual weight)-based cytotoxic chemotherapy doses are used to treat obese patients with cancer, particularly when the goal of treatment is cure. However, no study has examined dosage calculation...
In our Department, doses of chemotherapy in obese cancer patients are routinely calculated according to actual body weight. As some physicians question this policy, we prospectively evaluated the safety of this approach. Of 606 consecutive patients, 178 (29%) were obese, defined as body mass index ≥27.3 kg/m2 for females and ≥27.8 kg/m2 for males; full-dose chemotherapy was initiated in 147 (24%)...
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