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Purpose. To determine the maximum tolerated dose (MTD) of -methylene-10-deazaaminopterin (MDAM), a unique antifolate structurally similar to methotrexate (MTX), in the treatment of patients with solid tumors and to characterize toxicity and pharmacokinetic profiles of MDAM administered intravenously for five consecutive days repeated every 21days. Methods. A group of 18 patients with treatment-refractory...
Background:E7070 is a novel antitumor sulfonamide whichblocks the cell in G1 phase. A phase I study was initiated toinvestigate the toxicity, maximum tolerated dose (MTD), andpharmacokinetics of this compound when administered intravenously at adaily times five schedule once every three weeks. Patients and methods:Patients with solid tumors notamenable to standard forms of therapy were eligible...
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