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The endo-/sarcoplasmic reticulum Ca2+–Mg2+-adenosine triphosphatase (SERCA2) isoform of the sarco/endoplasmic reticulum Ca2+-ATPase is sensitive to cellular conditions of inflammation and oxidative stress as evidenced by the common appearance of 3-nitrotyrosine-modified forms of SERCA2 in aging and disease in both striated and smooth muscle of humans and rodent models. Structure–function studies of...
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