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Background High-fat diets may contribute to metabolic disease via postprandial changes in serum endotoxin and inflammation. It is unclear how dietary fat composition may alter these parameters. We hypothesized that a meal rich in n-3 (ω3) fatty acids would reduce endotoxemia and associated inflammation but a saturated or n-6 (ω6) fatty acid-rich meal would increase postprandial serum endotoxin concentrations...
Although increased consumption of ω-6 polyunsaturated fatty acids (PUFAs) in proportion with ω-3 PUFAs has been associated with the development of cardiovascular diseases, obesity, cancer, and inflammatory bowel diseases such as Crohn’s disease (CD), epidemiological findings have so far been heterogeneous. As bioavailability of PUFAs is dependent on both dietary consumption and metabolism by enzymes,...
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