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HintergrundLeukozyten-Endothel-Interaktionen stellen ein wichtiges Bindeglied zwischen Perfusionsstörungen und Entzündungsreaktionen dar. Die vorliegende Untersuchung sollte die Frage beantworten, welchen Anteil reduzierte Scherkräfte an Leukozyten-Endothel-Interaktionen besitzen, und ob durch hydrodynamische Störungen direkt Entzündungsreaktionen, wie die Induktion von „tissue factor“ (TF) ausgelöst...
On inflamed endothelium the cell surface protein E-selectin isexpressed which supports the initial process of attachment –capturing and rolling of leukocytes. A recombinant CHO cell linesecreting a soluble E-selectin-IgG chimera was cultivated competitively under serum free conditions in three different bioreactor systems: a 1 l Super-Spinner, a 2 l stirred tank bioreactor equipped with a spinfilter,...
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