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Purpose In a search for more effective combination chemotherapy for the treatment of metastatic melanoma, we conducted a phase I trial of a novel combination of docetaxel, temozolomide, and cisplatin. Methods Patients with inoperable or recurrent metastatic melanoma with a Zubrod performance status of 2 or less and adequate organ function were eligible. The dose of docetaxel was escalated between...
Purpose:A phase I trial of raltitrexed in combination withcisplatin in patients with locally advanced or metastatic squamous cellcarcinoma of the head and neck (SCCHN). Patients and methods:Eligible patients had locally advanced ormetastatic SCCHN. Cohorts of patients were treated with escalating doses ofraltitrexed (2.0 mg/m2 to 3.5 mg/m2) as a 15-minuteintravenous infusion immediately followed...
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