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The correct interpretation of many molecular biology experiments depends in an essential way on the accuracy and consistency of the existing annotation databases. Such databases are meant to act as repositories for our biological knowledge as we acquire and refine it. Hence, by definition, they are incomplete at any given time. In this paper, we describe a technique that improves our previous method...
While much of molecular biology research has led to a wealth of knowledge about individual cellular components and their functions, it has become increasingly clear that most cellular functions are carried out by complex networks of interconnected components, and that the characterization of isolated cellular components is not sufficient to understand the cell's complexity. In recent years, the development...
A fundamental problem in systems biology consists of determining the equilibrium points of genetic regulatory networks, since the knowledge of these points is often required in order to investigate important properties such as stability. Unfortunately, this problem amounts to computing the solutions of a system of nonlinear equations, and it is well known that this is a difficult problem as no existing...
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