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Based on the well established involvement of IL-1β in inflammatory hyperalgesia, we have assessed the possible role played by IL-1β in a murine model of bone cancer-induced pain. With this aim, we measured IL-1β levels at the region of the tibia and the spinal cord in mice bearing a tibial osteosarcoma induced by the inoculation of NCTC 2472 cells, and we tested whether the IL-1 receptor antagonist,...
Experiments were designed to elucidate the involvement of nitric oxide (NO) in the antihyperalgesic effect induced by the activation of peripheral μ-opioid receptors on osteosarcoma-induced thermal hyperalgesia in mice. Since this pathway has previously been shown to be involved in the antihyperalgesic effect induced by some drugs—including opiates—on inflammatory pain, experiments were also performed...
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