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With the advent of precision medicine, biomarkers have recently come into focus as a promising tool for early cancer detection and treatment individualization. In particular, much interest has been shown in the oral microbiome as a promising potential cancer biomarker, especially for head and neck cancers. The American Cancer Society estimates that there will be nearly 50,000 new cases and roughly...
Machine learning classifiers help physicians to make near-perfect diagnoses, minimizing costs and time. Since medical data usually contains a high degree of uncertainty and ambiguity, proper ordering and classification require a proper comparative performance analysis of machine learning classifiers. Machine learning classifiers are applied on the Ovarian Cancer Dataset. Ovarian cancer is the fifth...
Microarrays have now gone from obscurity to being almost ubiquitous in biological research. At the same time, the statistical methodology for microarray analysis has progressed from simple visual assessments of results to novel algorithms for analyzing changes in expression profiles. In a micro-RNA (miRNA) or gene-expression profiling experiment, the expression levels of thousands of genes/miRNAs...
Microarray technology has enabled us to simultaneously measure the expression of thousands of genes. Using this high-throughput technology, we can examine subtle genetic changes between biological samples and build predictive models for clinical applications. Although microarrays have dramatically increased the rate of data collection, sample size is still a major issue when selecting features. Previous...
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