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Résumé Depuis deux décennies, les connaissances sur la cancérogenèse ont grandement progressé. L’origine monoclonale des tumeurs humaines et leur évolution en plusieurs étapes (initiation, promotion, progression) n’ont pas été remises en question, mais l’ensemble du processus apparaît beaucoup plus complexe qu’on ne le pensait. En particulier, l’existence de mécanismes de défense puissants et multiples...
We present the results of a quantitative assessment of the lung cancer risk associated with occupational exposure to refractory ceramic fibers (RCF). The primary sources of data for our risk assessment were two long-term oncogenicity studies in male Fischer rats conducted to assess the potential pathogenic effects associated with prolonged inhalation of RCF. An interesting feature of the data was...
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