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Opinion statement Purpose of review Systemic sclerosis (SSc) has been difficult to treat due to disease heterogeneity and an incomplete understanding of the molecular mechanisms underlying pathogenesis. Some patients show improvement on existing or experimental therapies while others show no significant response. Due to these challenges, clinical trials often do not meet their primary clinical endpoints...
Background Accumulated to-date gene microarray data on Acute Respiratory Distress Syndrome (ARDS) in the Gene Expression Omnibus (GEO) represent a rich source for identifying new unsuspected targets and mechanisms of ARDS. The recently developed expression-based genome-wide association study (eGWAS) for analysis of GEO data was successfully used for analysis of gene expression of comparatively noncomplex...
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