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The recent explosion in availability of gene and protein expression data for cancer detection has necessitated the development of sophisticated machine learning tools for high dimensional data analysis. Previous attempts at gene expression analysis have typically used a linear dimensionality reduction method such as Principal Components Analysis (PCA). Linear dimensionality reduction methods do not...
Background In gene expression analysis, overlapping genes, splice variants, and fusion transcripts are potential sources of data analysis artefacts, depending on how the observed intensity is assigned to one, or more genes. We here exemplify this by an in-depth analysis of the INS-IGF2 fusion transcript, which has recently been reported to be among the highest expressed transcripts in human pancreatic...
Cocaine administration in the brain alters gene expression via dopamine and glutamate receptor-mediated intracellular signaling cascades. The current study was designed to identify alterations in the total proteome in the rat dorsal striatum in response to intraperitoneal injection of cocaine (20 mg/kg). The results demonstrated that alterations of specific proteins at 20, 120, and 360 min following...
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