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Morphological change in endothelial cells is an initial and crucial step in the process of establishing a functional vascular network. Following or associated with differentiation and proliferation, endothelial cells elongate and assemble into linear cord-like vessels, subsequently forming a perfusable vascular tube. In vivo and in vitro studies have begun to outline the underlying genetic and signaling...
Angiogenesis is a physiological process involving the formation of new blood vessels from existing vessels. It is essential for the growth of primary tumor and local tumor invasion and metastasis. This chapter reviews the general angiogenesis process, the endogenous factors that regulate angiogenesis, and therapeutic angiogenesis inhibitors. It also reviews the effect of vitamin D on angiogenesis...
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